Products

Anti-CD20 × Anti-CD28 Bispecific Antibody (TAND-L027)

Recombinant Anti-CD20 × Anti-CD28 Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb is capable of inducing T-cell activation and effective tumor-cell killing without a signal through the TCR/CD3 complex. It was designed for the treatment of lymphoma.      

Specifications
Targets
CD20 & CD28
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
CD20
Host
Mouse
Clone
1F5
Target 2
CD28
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Lymphoma
Targets
Target 1
CD20
Gene ID
931
UniProt ID
A0A024R507
Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2
Target 2
CD28
Gene ID
940
UniProt ID
B4E0L1
Alternative Names
CD28; CD28 molecule; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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