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Anti-CD22 × Anti-CD19 Bispecific Antibody (TAND-L038)

Recombinant Anti-CD22 × Anti-CD19 Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to one cell surface antigens and the other two to the other cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. It was designed for the treatment of breast cancer, non-Hodgkin's lymphoma (NHL), acute myeloid leukemia (AML).      

Specifications
Targets
CD22 & CD19
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
CD22
Host
Human
Target 2
CD19
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Breast cancer, Non-Hodgkin's lymphoma (NHL), Acute myeloid leukemia (AML)
Targets
Target 1
CD22
Gene ID
933
UniProt ID
P20273
Alternative Names
CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14
Target 2
CD19
Gene ID
930
UniProt ID
P15391
Alternative Names
CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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