Recombinant Anti-CD47 × Anti-SIRPA Bispecific Antibody (Tandem Diabody) (CAT#: TAND-L034)
Recombinant Anti-CD47 × Anti-SIRPA Bispecific Antibody (Tandem Diabody) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. Tandem Diabodies do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than tandem scFvs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with tandem scFvs. This BsAb is capable of inhibiting signaling of their cognate factors and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It was designed for the treatment of breast cancer, non-Hodgkin's lymphoma (NHL), acute myeloid leukemia (AML).
Specific Inquiry
Specifications
- Target
- CD47 & SIRPA
- Type
- Tandem Diabody
- Species Reactivity
- Human
- Target 1
- CD47
- Host Species 1
- Human
- Target 2
- SIRPA
- Host Species 2
- Human
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Breast cancer; Non-Hodgkin's lymphoma (NHL); Acute myeloid leukemia (AML)
Target
- Target 1
- CD47
- Gene ID
- 961
- UniProt ID
- Q08722
- Alternative Names
- CD47; CD47 molecule; IAP; OA3; MER6; leukocyte surface antigen CD47; CD47 glycoprotein; Rh-related antigen; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; antigenic surface determinant protein OA3; antigen
- Target 2
- SIRPA
- Gene ID
- 140885
- UniProt ID
- P78324
- Alternative Names
- SIRPA; signal-regulatory protein alpha; BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1; tyrosine-protein phosphatase non-receptor type substrate 1; myd-1 antigen; inhibitory receptor SHPS-1; macrophage fusion receptor; CD172 antigen-like family member A; tyrosine phosphatase SHP substrate 1; brain-immunoglobulin-like molecule with tyrosine-based activation motifs
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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