Products

Anti-CD47 × Anti-SIRPA Bispecific Antibody (TAND-L034)

Recombinant Anti-CD47 × Anti-SIRPA Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb is capable of inhibiting signaling of their cognate factors and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It was designed for the treatment of breast cancer, non-Hodgkin's lymphoma (NHL), acute myeloid leukemia (AML).      

Specifications
Targets
CD47 & SIRPA
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
CD47
Host
Human
Target 2
SIRPA
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Breast cancer; Non-Hodgkin's lymphoma (NHL); Acute myeloid leukemia (AML)
Targets
Target 1
CD47
Gene ID
961
UniProt ID
Q08722
Alternative Names
CD47; CD47 molecule; IAP; OA3; MER6; leukocyte surface antigen CD47; CD47 glycoprotein; Rh-related antigen
Target 2
SIRPA
Gene ID
140885
UniProt ID
P78324
Alternative Names
SIRPA; signal-regulatory protein alpha; BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1; tyrosine-protein phosphatase non-receptor type substrate 1; myd-1 antigen; inhibitory receptor SHPS-1; macrophage fusion receptor; CD172 antigen-like family member A; tyrosine phosphatase SHP substrate 1; brain-immunoglobulin-like molecule with tyrosine-based activation motifs

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

45-1 Ramsey Road, Shirley, NY 11967, USA     Tel: 1-631-871-5806    Fax: 1-631-207-8356    Email:
Terms of Service-Privacy Policy     © 2007 - 2018 Creative-Biolabs All Rights Reserved