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Anti-CD8 × Anti-CD3 Bi-specific T-cell engagers (BITE-L052)

Recombinant Anti-CD8 × Anti-CD3 Bi-specific T-cell engagers (BiTE) expressed as a single-chain Fv (scFv) from anti-CD8 VH and VL region fused with a scFv of anti-CD3 VH and VL region with a His-tag at the C-terminus. This BsAb exists as a monomer under non-reducing and reducing condition. It is capable of targeting effector T cells to induce T-cell-mediated cytotoxicity of cells associated with a disease, such as ADIS.      

Specifications
Targets
CD8 & CD3
Type
BiTE
Expression Host
CHO
Species Reactivity
Mouse
Target 1
CD8
Host
goat
Target 2
CD3
Host
goat
Clone
--
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
ADIS
Targets
Target 1
CD8
Gene ID
12525
UniProt ID
P01731
Alternative Names
CD8; CD8 antigen, alpha chain; Ly-2; Ly-B; Ly-35; Lyt-2; BB154331
Target 2
CD3
Gene ID
12501
UniProt ID
A6H6M1
Alternative Names
CD3; CD3 antigen, epsilon polypeptide; T3e; AI504783; CD3epsilon

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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