Products

Anti-DNMT1 × Anti-SHH Bispecific Antibody (NANO-L003)

Recombinant Anti-DNMT1 × Anti-SHH Bispecific Antibody (Bi-Single Domain Antibody) comprises two monomeric VH-like binding entities of different specificities that are fused to each other in a bivalent-bispecific manner. Bi-Single Domain Antibody is only consisted of the VHHs. The loss of light chain and constant fragment in bi-Single Domain Antibody does not eliminate their functional antigen-binding capacity, but even endows them non-substitutable advantage in application. This BsAb can block Hedgehog binding to PTCH, downregulate of DNMT1 and block DNA methylation. It was designed for the treatment of diseases associated with hormone refractory breast cancer (HRBC).      

Specifications
Targets
DNMT1 & SHH
Type
Bi-Single Domain Antibody
Expression Host
CHO
Species Reactivity
Human
Target 1
DNMT1
Host
Mouse
Target 2
SHH
Host
Rabbit
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Hormone refractory breast cancer (HRBC)
Targets
Target 1
DNMT1
Gene ID
1786
UniProt ID
I6L9H2
Alternative Names
AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN
Target 2
SHH
Gene ID
6469
UniProt ID
Q15465
Alternative Names
TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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