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Anti-DR4 × Anti-DR5 Bi-specific T-cell engagers (BiTE, 3631-G09(SL231)) (BITE-MZ047)

This antibody is a dual DR4 and DR5 receptor agonist which binds to both human DR4 and human DR5, but not to mouse DR5. The dual agonist SBP induces spheroiod apoptosis better than individual receptor antibodies and the combination of individual receptor antibodies. It is also capable of initiating a Type I apoptotic response and activating caspases more potently, as well as inducing spheroiod apoptosis.      

Specifications
Targets
DR4 & DR5
Type
BiTE
Expression Host
CHO
Species Reactivity
Human
Target 1
DR4
Host
Human
Target 2
DR5
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
ELISA
Related Disease
Pancreatic cancer, colon cancer, breast cancer
Targets
Target 1
DR4
Gene ID
8797
UniProt ID
O00220
Alternative Names
TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; DR4; APO2; CD261; TRAILR1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A
Target 2
DR5
Gene ID
8795
UniProt ID
O14763
Alternative Names
TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; tumor necrosis factor receptor superfamily member 10B; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; TNF receptor superfamily member 10b; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer)

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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