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Anti-EGFR × Anti-CD3 Bi-specific T-cell engagers (BiTE, 7B3/CD3) (BITE-LC003)

The anti-CD3/EGFR antibody specifically binds to a cryptic epitope formed by 287th to 302nd amino acid sequence of the EGFR and a surfce antigen CD3. By inducing cytotoxicity on tumor cells, the bispecific antibody can be potentially used in the treatment of cancers such as glioma and epidermoid carcinoma.      

Specifications
Targets
EGFR & CD3
Type
BiTE
Expression Host
CHO
Species Reactivity
Human
Target 1
EGFR
Host
Mouse
Clone
7B3
Target 2
CD3
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FC, ELISA
Related Disease
Glioma, Epidermoid carcinoma
Targets
Target 1
EGFR
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Target 2
CD3
Alternative Names
CD3; CD3 T-Cell Co-receptor;CD3D; CD3E; CD3G

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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