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Anti-EGFR × Anti-ErbB-2 Bispecific Antibody (IgG-IgG, H2E-01) (BSIG-MZ002)

This anti-EGFR/anti-HER2 bispecific antibody includes an anti-EGFR DARPin and an anti-HER2 antibody, which exhibits excellent anticancer effect on gastric cancer cells such as MKN45, SNU638, or N87. It is also capable of causing an inhibitory effect on cancer cell proliferation as well as an internalization of HER2 and EGFR on the cell surface into the cell.      

Specifications
Targets
EGFR & ErbB-2
Type
IgG-IgG
Expression Host
CHO
Species Reactivity
Human
Target 1
EGFR
Host
Human
Clone
DARPin-01
Target 2
ErbB-2
Host
Human
Clone
Herceptin (also named Trastuzumab)
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
Fluorescence imaging
Related Disease
Gastric cancer
Targets
Target 1
EGFR
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Target 2
ErbB-2
Gene ID
2064
UniProt ID
P04626
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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