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Anti-EGFR × Anti-ErbB-2 Bispecific Antibody (IgG-IgG, TC-BsAb) (BSIG-MZ003)

This bispecific antibody is significantly more potent in inhibiting the growth of breast cancer cell lines than trastuzumab, cetuximab, and trastuzumab plus cetuximab, suggesting its potential use for treating breast cancer. It is also capable of inducing internalization of both EGFR and ErbB2 on cell surface.      

Specifications
Targets
EGFR & ErbB-2
Type
IgG-IgG
Expression Host
CHO
Species Reactivity
Human
Target 1
EGFR
Host
Human
Clone
Cetuximab
Target 2
ErbB-2
Host
Human
Clone
Trastuzumab
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
ELISA
Related Disease
Breast cancer
Targets
Target 1
EGFR
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Target 2
ErbB-2
Gene ID
2064
UniProt ID
P04626
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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