Recombinant Anti-EGFR × Anti-ErbB-3 Bispecific Antibody (Fab2, PB4522) (CAT#: FAB-MZ007)
This bispecific antibody comprising a first antigen-binding site that binds EGFR and a second antigen-binding site that binds ErbB-3 can inhibit the proliferation of pancreatic cancer cells. It is capable of induceing ADCC (Dependent cell-mediated cytotoxicity) activity towards the EGFR amplified cell line, which is an important anti-tumour mechanism of action for therapeutic antibodies in cancer.
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Specifications
- Target
- EGFR & ErbB-3
- Type
- Fab2
- Species Reactivity
- Human
- Target 1
- EGFR
- Host Species 1
- Human
- Target 2
- ErbB-3
- Host Species 2
- Human
- Application
- FC, ADCC Reporter Bioassay
- Related Disease
- Pancreatic cancer
Target
- Target 1
- EGFR
- Gene ID
- 1956
- UniProt ID
- P00533
- Alternative Names
- EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
- Target 2
- ErbB-3
- Gene ID
- 2065
- UniProt ID
- P21860
- Alternative Names
- ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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