Recombinant Anti-EGFR × Anti-FcγRIII Bispecific Antibody (CrossMab) (CAT#: CROSS-L001)

Recombinant Anti-EGFR × Anti-FcγRIII Bispecific Antibody (CrossMab) has been generated by applying the Crossmab format to generate an IgG shaped entity that binds each ligand with one arm. This BsAb is capable of targeting the tumor and recruiting NK effector cells via binding to the FcγRIII of the NK cells. It was designed for the treatment of renal cell carcinoma.


Specific Inquiry
  • Size:
  • Conjugation:
  • Datasheet
  • MSDS
  • COA

Specifications

  • Target
  • EGFR & FcγRIII
  • Type
  • CrossMab
  • Species Reactivity
  • Human
  • Target 1
  • EGFR
  • Host Species 1
  • Human
  • Target 2
  • FcγRIII
  • Host Species 2
  • Human
  • Application
  • FuncS, Promising therapeutic agent
  • Related Disease
  • Renal cell carcinoma

Target

  • Target 1
  • EGFR
  • Alternative Names
  • EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1;
  • Target 2
  • FcγRIII
  • Alternative Names
  • FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA; low affinity immunoglobulin gamma Fc region receptor III-A; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc-gamma receptor III-2 (CD 16); immunoglobulin G Fc receptor III; Fc fragment of IgG, low affinity III, receptor for (CD16)

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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