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Anti-EGFR × Anti-HER2 Bispecific Antibody (TAND-L028)

Recombinant Anti-EGFR × Anti-HER2 Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb is capable of blocking two HER family members has been demonstrated by simultaneously blocking EGFR as well as HER2. BsAb-mediated simultaneous interference with two (or more) RTK signaling pathways, by inactivating either the RTKs or their ligand, can reduce the possibility of such escape mechanisms and, hence, improve therapeutic efficacy. It was designed for the treatment of breast cancer, colon cancer, lung cancer and pancreatic cancer.      

Specifications
Targets
EGFR & HER2
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
EGFR
Host
Rabbit
Clone
H425
Target 2
HER2
Host
Rabbit
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Breast cancer, Colon cancer, Lung cancer, Pancreatic cancer
Targets
Target 1
EGFR
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Target 2
HER2
Gene ID
2064
UniProt ID
P04626
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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