Products

Anti-EGFR × Anti-IGFR Bispecific Antibody (TAND-L052)

Recombinant Anti-EGFR × Anti-IGFR Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. This BsAb can simultaneously block two receptors. It was designed for the treatment of Colorectal carcinoma, Cervical carcinoma, Breast carcinoma, Pancreatic carcinoma.      

Specifications
Targets
EGFR & IGFR
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
EGFR
Host
Human
Clone
IMC-11F8
Target 2
IGFR
Host
Human
Clone
IMC-A12
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Colorectal carcinoma, Cervical carcinoma, Breast carcinoma, Pancreatic carcinoma
Targets
Target 1
EGFR
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Target 2
IGFR
Gene ID
3480
UniProt ID
P08069
Alternative Names
IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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