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Anti-EGFRvIII × Anti-CD133 Bispecific Antibody (TAND-L002)

Recombinant Anti-EGFRvIII× Anti-CD133 Bispecific Antibody (TandAb) has been generated by applying the Crossmab format to generate an IgGshaped entity that binds each ligand with one arm. This BsAb is capable of redirecting lysis of B lymphoma cells by preactivated PBMC from healthy donors. It was designed for the treatment of hodgkin's Lymphoma.      

Specifications
Targets
EGFRvIII & CD133
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
EGFRvIII
Host
Mouse
Clone
MR 1-1
Target 2
CD133
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Lymphoma
Targets
Target 1
EGFRvIII
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Target 2
CD133
Gene ID
8842
UniProt ID
O43490
Alternative Names
PROM1; prominin 1; RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061; prominin-1; hProminin; antigen AC133; prominin-like protein 1; hematopoietic stem cell antigen

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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