Products

Anti-FcγRII × Anti-CD79B Bispecific Antibody (TAND-L005)

Recombinant Anti-FcγRII × Anti-CD79B Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb is capable of triggering the FcγRII-mediated inhibition. It was designed for the treatment of allergy, asthma and inflammation.      

Specifications
Targets
FcγRII & CD79B
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
FcγRII
Host
Mouse
Target 2
CD79B
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Allergy, asthma, inflammation
Targets
Target 1
FcγRII
Gene ID
2213
UniProt ID
P31994
Alternative Names
CD32; FCG2; CD32B; FCGR2; IGFR2
Target 2
CD79B
Gene ID
974
UniProt ID
P40259
Alternative Names
B29; IGB; AGM6

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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