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Anti-GD2 × Anti-FcγRIII Bispecific Antibody (TAND-L026)

Recombinant Anti-GD2 × Anti-FcγRIII Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb is capable of targeting the tumor and recruiting NK effector cells via binding to the FcγRIII subunit of the NK cells. It was designed for the treatment of neuroblastoma and osteosarcoma.      

Specifications
Targets
GD2 & FcγRIII
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
GD2
Host
Human
Target 2
FcγRIII
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Neuroblastoma and Osteosarcoma
Targets
Target 1
GD2
Alternative Names
Ganglioside G2; GD2; Ganglioside
Target 2
FcγRIII
Gene ID
2214
UniProt ID
M9MML0
Alternative Names
FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA; low affinity immunoglobulin gamma Fc region receptor III-A; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc-gamma receptor III-2 (CD 16); immunoglobulin G Fc receptor III; Fc fragment of IgG, low affinity III, receptor for (CD16)

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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