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Anti-HER2 × Anti-CD3 Bispecific Antibody (Triomab, Ertumaxomab) (BSAB-L005)

Recombinant Anti-HER2 × Anti-CD3 Bispecific Antibody (Triomab), Expressed as an anti-HER2 scFv region fused with an anti-CD3 monoclonal antibody with a His-tag at the C-terminus. Exists as a monomer under non-reducing and reducing condition. The complex is capable of targeting effector T cells to induce T-cell-mediated cytotoxicity of cells associated with a disease, such as Gastric and esophageal cancers, breast cancer.      

Specifications
Targets
HER2 & CD3
Type
BsIgG: Triomab
Expression Host
CHO
Species Reactivity
Human
Target 1
HER2
Host
Mouse IgG2a
Target 2
CD3
Host
Rat IgG2b λ
Purity
>95% judged by SDS-PAGE under reducing condition
Related Disease
Gastric and esophageal cancers, breast cancer
Targets
Target 1
HER2
Gene ID
2064
UniProt ID
P04626
Alternative Names
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
Target 2
CD3
Alternative Names
CD3; cluster of differentiation 3; CD3γ; CD3δ; CD3ε; CD3ζ

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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