Products

Anti-HER2 × Anti-CD3 Bi-specific T-cell engagers (BITE-L030)

Recombinant Anti-HER2 × Anti-CD3 Bi-specific T-cell engagers (BiTE) was expressed as a single-chain Fv (scFv) from anti-HER2 VH and VL region fused with a scFv of anti-CD3 VH and VL region with a His-tag at the C-terminus. This BsAb exists as a monomer under non-reducing and reducing condition. It is capable of targeting effector T cells to induce T-cell-mediated cytotoxicity of cells associated with a disease, such as Breast cancer, prostate cancer, non-small cell lung cancer, bladder cancer, ovarian cancer, gastric cancer, colon cancer, esophageal cancer.      

Specifications
Targets
HER2 & CD3
Type
BiTE
Expression Host
CHO
Species Reactivity
Human
Target 1
HER2
Host
Mouse
Clone
——
Target 2
CD3
Host
Mouse
Clone
OKT3
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Breast cancer, prostate cancer, non-small cell lung cancer, bladder cancer, ovarian cancer, gastric cancer, colon cancer, esophageal cancer
Targets
Target 1
HER2
Gene ID
2064
UniProt ID
P04626
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2
Target 2
CD3
Gene ID
916
UniProt ID
P07766
Alternative Names
CD3E; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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