Products

Anti-HER2 × Anti-CD3 Bi-specific T-cell engagers (BITE-L053)

Recombinant Anti-HER2 × Anti-CD3 Bi-specific T-cell engagers (BiTE) expressed as a single-chain Fv (scFv) from anti-ERBB2 VH and VL region fused with a scFv of anti-CD3 VH and VL region with a His-tag at the C-terminus. This BsAb exists as a monomer under non-reducing and reducing condition. It is capable of targeting effector T cells to induce T-cell-mediated cytotoxicity of cells associated with a disease, such as c-ErbB-2-positive tumor.      

Specifications
Targets
HER2 & CD3
Type
BiTE
Expression Host
CHO
Species Reactivity
Mouse
Target 1
HER2
Host
goat
Clone
SER4
Target 2
CD3
Host
goat
Clone
KT3.1
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
c-ErbB-2-positive tumor
Targets
Target 1
HER2
Gene ID
13866
UniProt ID
P70424
Alternative Names
Erbb2; erb-b2 receptor tyrosine kinase 2; Neu; HER2; HER-2; c-neu; Erbb-2; c-erbB2
Target 2
CD3
Gene ID
12501
UniProt ID
A6H6M1
Alternative Names
CD3; CD3 antigen, epsilon polypeptide; T3e; AI504783; CD3epsilon

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

45-1 Ramsey Road, Shirley, NY 11967, USA     Tel: 1-631-871-5806    Fax: 1-631-207-8356    Email:
Terms of Service-Privacy Policy     © 2007 - 2017 Creative-Biolabs All Rights Reserved