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Anti-HER2 × Anti-HER3 Bispecific Antibody (BiTE, MM-111) (BSAB-L016)

Recombinant Anti-HER2 × Anti-HER3 Bi-specific T-cell engagers (BiTE) expressed as a single-chain Fv (scFv) from anti-HER2 VH and VL region fused with a scFv of anti-HER3 VH and VL region with a His-tag at the C-terminus. It was designed for the treatment of Gastric and esophageal cancers Breast cancer.      

Specifications
Targets
HER2 & HER3
Type
HSA body
Expression Host
CHO
Species Reactivity
Human
Target 1
HER2
Host
Human
Clone
Trastuzumab
Target 2
HER3
Host
Humanized IgG1 k
Clone
Duligotuzumab
Purity
>95% judged by SDS-PAGE under reducing condition
Related Disease
Gastric and esophageal cancers, breast cancer
Targets
Target 1
HER2
Gene ID
2064
UniProt ID
P04626
Alternative Names
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
Target 2
HER3
Gene ID
2065
UniProt ID
P21860
Alternative Names
HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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