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Anti-HER3 × Anti-ErbB-2 Bispecific Antibody (Bi-sdAb, ALM) (NANO-MZ002)

This bispecific antibody is composed of the A5 scFv and the ML3.9 scFv which specifically binds to both HER3 and HER2/neu, respectively. It is capable of mediating a reduction in the quantity of HER2/neu and HER3 on the surface of tumor cells, which is a similar mechanism to internalization.      

Specifications
Targets
HER3 & ErbB-2
Type
Bi-sdAb
Expression Host
CHO
Species Reactivity
Human
Target 1
HER3
Host
Human
Clone
A5
Target 2
ErbB-2
Host
Human
Clone
ML3.9
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
PET-CT imaging
Related Disease
Breast cancer
Targets
Target 1
HER3
Gene ID
2065
UniProt ID
P21860
Alternative Names
ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1
Target 2
ErbB-2
Gene ID
2064
UniProt ID
P04626
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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