Products

Anti-IL-1α × Anti-IL-1β Bispecific Antibody (DVD-L004)

Recombinant Anti-IL-1α × Anti-IL-1β Bispecific Antibody (DVD-Ig) is comprised of a whole IL-1α-binding 'IgG' (with Fc region) and additional variable regions that bind IL-1β fused 'on top' of the existing variable regions. This BsAb is capable of inhibiting signaling of their cognate factors and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It was designed for the treatment of rheumatoid arthritis.      

Specifications
Targets
IL-1α & IL-1β
Type
DVD-Ig
Expression Host
CHO
Species Reactivity
Human
Target 1
IL-1α
Host
Human
Clone
3D12.E3
Target 2
IL-1β
Host
Human
Clone
13F5.G5
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Rheumatoid arthritis
Targets
Target 1
IL-1α
Gene ID
3552
UniProt ID
P01583
Alternative Names
IL1; IL-1A; IL1F1; IL1-ALPHA
Target 2
IL-1β
Gene ID
3553
UniProt ID
P01584
Alternative Names
IL-1; IL1F2; IL1-BETA

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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