Products

Anti-MET × Anti-EGFR Bispecific Antibody (TAND-L008)

Recombinant Anti-MET × Anti-EGFR Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb can simultaneously block two receptors. It was designed for the treatment of colorectal cancer, pancreatic cancer, head and neck cancer, and non-small cell lung cancer (NSCLC).      

Specifications
Targets
MET & EGFR
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
MET
Host
Mouse
Target 2
EGFR
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Colorectal cancer, Pancreatic cancer, Head and neck cancer, and Non-small cell lung cancer (NSCLC)
Targets
Target 1
MET
Gene ID
4233
UniProt ID
A0A024R759
Alternative Names
MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor
Target 2
EGFR
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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