Products

Anti-MET × Anti-HER2 Bispecific Antibody (DVD-L001)

Recombinant Anti-MET × Anti-HER2 Bispecific Antibody (DVD-Ig) is comprised of a whole MET-binding 'IgG' (with Fc region) and additional variable regions that bind HER2 fused 'on top' of the existing variable regions. This BsAb is capable of blocking c-MET as well as HER2 simultaneously. BsAb-mediated simultaneous interference with two (or more) RTK signaling pathways, by inactivating either the RTKs or their ligand, should reduce the possibility of such escape mechanisms and, hence, improve therapeutic efficacyinhibiting their signaling and suppressing tumor cells growth. It was designed for the treatment of metastatic cancer.      

Specifications
Targets
MET & HER2
Type
DVD-Ig
Expression Host
CHO
Species Reactivity
Human
Target 1
MET
Host
Mouse
Clone
AbF46
Target 2
HER2
Host
Human
Clone
——
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Metastatic cancer
Targets
Target 1
MET
Gene ID
4233
UniProt ID
A0A024R759
Alternative Names
MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor
Target 2
HER2
Gene ID
2064
UniProt ID
P04626
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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