Products

Anti-PSCA × Anti-CD8 Bispecific Antibody (TAND-L014)

Recombinant Anti-PSCA × Anti-CD8 Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb can retarget of T cells to tumor cells. It was designed for the treatment of prostate cancer.      

Specifications
Targets
PSCA & CD8
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
PSCA
Host
Human
Target 2
CD8
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Prostate cancer
Targets
Target 1
PSCA
Gene ID
8000
UniProt ID
D3DWI6
Alternative Names
PSCA; prostate stem cell antigen; PRO232
Target 2
CD8
Gene ID
925
UniProt ID
P01732
Alternative Names
CD8A; CD8a molecule; CD8; MAL; p32; Leu2; T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte antigen; CD8 antigen, alpha polypeptide (p32); T-lymphocyte differentiation antigen T8/Leu-2

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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