Products

Anti-VEGF × Anti-DLL4 Bispecific Antibody (NANO-L002)

Recombinant Anti-VEGF & Anti-DLL4 Bispecific Antibody (Bi-Single Domain Antibody) comprises two monomeric VH-like binding entities of different specificities that are fused to each other in a bivalent-bispecific manner.Bi-Single Domain Antibody is only consisted of the VHHs. The loss of light chain and constant fragment in bi-Single Domain Antibody does not eliminate their functional antigen-binding capacity, but even endows them non-substitutable advantage in application. This BsAb is capable of inhibiting signaling of their cognate factors and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone.It was designed for the treatment of diseases associated with VEGF-mediated vascular effects for generation.      

Specifications
Targets
VEGF & DLL4
Type
Bi-Single Domain Antibody
Expression Host
CHO
Species Reactivity
Human
Target 1
VEGF
Host
Llama
Target 2
DLL4
Host
Llama
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Central nervous system derived tumors
Targets
Target 1
VEGF
Gene ID
7422
UniProt ID
P15692
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor
Target 2
DLL4
Gene ID
54567
UniProt ID
Q9NR61
Alternative Names
DLL4; delta-like 4 (Drosophila); hdelta2; delta-like protein 4; delta4; delta 4; delta ligand 4; notch ligand DLL4; delta-like 4 homolog; delta-like 4 protein; notch ligand delta-2; drosophila Delta homolog 4

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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