Products

Anti-VEGF × Anti-DLL4 Bispecific Antibody (DVD-L008)

Recombinant Anti-VEGF × Anti-DLL4 Bispecific Antibody (DVD-Ig) is comprised of a whole VEGF-binding 'IgG' (with Fc region) and additional variable regions that bind DLL4 fused 'on top' of the existing variable regions. This BsAb is capable of inhibiting signaling of their cognate factors and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It was designed for the treatment of diseases associated with VEGF-mediated vascular effects for generation.      

Specifications
Targets
VEGF & DLL4
Type
DVD-Ig
Expression Host
CHO
Species Reactivity
Human
Target 1
VEGF
Host
Mouse
Target 2
DLL4
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Diseases associated with VEGF-mediated vascular effects for generation
Targets
Target 1
VEGF
Gene ID
7422
UniProt ID
P15692
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor
Target 2
DLL4
Gene ID
54567
UniProt ID
Q9NR61
Alternative Names
DLL4; delta-like 4 (Drosophila); hdelta2; delta-like protein 4; delta4; delta 4; delta ligand 4; notch ligand DLL4; delta-like 4 homolog; delta-like 4 protein; notch ligand delta-2; drosophila Delta homolog 4

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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