Products

Anti-VEGF × Anti-VEGF-B Bispecific Antibody (TAND-L043)

Recombinant Anti-VEGFA & Anti-VEGFB Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb is capable of inhibiting signaling of their cognate proangiogenics and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It was designed for the treatment of central nervous system derived tumors.      

Specifications
Targets
VEGF & VEGF-B
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
VEGF
Host
Mouse
Target 2
VEGF-B
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Central nervous system derived tumors
Targets
Target 1
VEGF
Gene ID
7422
UniProt ID
P15692
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor
Target 2
VEGF-B
Gene ID
7423
UniProt ID
P49765
Alternative Names
VRF; VEGFL; VEGFB; vascular endothelial growth factor B

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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