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Anti-VEGFR2 × Anti-VEGFR3 Bispecific Antibody (TAND-L046)

Recombinant Anti-VEGFR2 × Anti-VEGFR3 Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. The BsAb binds to both VEGFR2 and VEGFR3 and blocks interaction between VEGF/VEGFR2, VEGF-C/VEGFR2, and VEGF-C/VEGFR3. It was designed for the treatment of various tumors.      

Specifications
Targets
VEGFR2 & VEGFR3
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
VEGFR2
Host
Human
Target 2
VEGFR3
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Various tumors
Targets
Target 1
VEGFR2
Gene ID
3791
UniProt ID
A0A024RD88
Alternative Names
KDR; kinase insert domain receptor; FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; soluble VEGFR2
Target 2
VEGFR3
Gene ID
2324
UniProt ID
P35916
Alternative Names
FLT4; PCL; FLT-4; FLT41; LMPH1A; VEGFR3; VEGFR-3

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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