Products

Bivalirudin (TP-075CL)

Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important to monitor changes in hematocrit, activated partial thromboplastin time, international normalized ratio and blood pressure.
This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.      

Specifications
Classify
Protein therapeutics providing a novel function or activity: Haemostasis and thrombosis
Therapeutic
Bivalirudin
Trade Name
Angiomax
Function
Synthetic hirudin analogue; specifically binds both the catalytic site and the anion-binding exosite of circulating and clot-bound thrombin
Examples of Clinical Use
Reduce blood-clotting risk in coronary angioplasty and heparin-induced thrombocytopaenia
References
Synonyms
Not Available

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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