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Anti-M1S1 (clone C16)-PEG6-Aur3377 ADC (CAT#: ADC-096LZY)

This ADC product is composed of an anti-M1S1 antibody (clone C16) conjugated via PEG6-linker to Aur3377 (C16-PEG6-Aur3377). It has demonstrated a response in pancreatic cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/if_selected.jpg
Figure 2 IF staining of human cell line A-431
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/893_A3_7_blue_red_green.jpg
Normal Tissue
Figure 3 Urinary bladder
Figure 3 Urinary bladder
(Urothelial cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43104/93730_A_6_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184292-TACSTD2
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184292-TACSTD2

Specifications

  • Antibody Overview
  • Anti-M1S1 C16 Antibody
  • Clone
  • C16
  • Antibody Conjugation
  • transglutaminase-mediated site-specific conjugation
  • Linker
  • Amino-PEG6-based linker
  • Linker Class/Description
  • Class: Noncleavable linker
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
  • Drug
  • Aur3377
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
  • Alternative Names
  • TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733;

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Mouse Antibody

CAT Product Name Application Type
TAB-0089CL-S(P) Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (TAB-0089CL-S(P)) WB, Inhib, Stim, BI Mouse scFv
TAB-0090CL-S(P) Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (TAB-0090CL-S(P)) WB, Inhib, Stim, BI Mouse scFv
TAB-0091CL-S(P) Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (TAB-0091CL-S(P)) WB, Inhib, Stim, BI Mouse scFv
TAB-0089CL-F(E) Mouse Anti-TACSTD2 Recombinant Antibody; Fab Fragment (TAB-0089CL-F(E)) WB, Inhib, Stim, BI Mouse Fab
TAB-0090CL-F(E) Mouse Anti-TACSTD2 Recombinant Antibody; Fab Fragment (TAB-0090CL-F(E)) WB, Inhib, Stim, BI Mouse Fab

Humanized Antibody

CAT Product Name Application Type
TAB-504CT Humanized Anti-TACSTD2 Recombinant Antibody (TAB-504CT) FC, WB, ELISA Humanized IgG
TAB-504CT-S(P) Humanized Anti-TACSTD2 Recombinant Antibody; scFv Fragment (TAB-504CT-S(P)) FC, WB, ELISA Humanized scFv
TAB-504CT-F(E) Humanized Anti-TACSTD2 Recombinant Antibody; Fab Fragment (TAB-504CT-F(E)) FC, WB, ELISA Humanized Fab

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4446 Hi-Affi™ Recombinant Rabbit Anti-TACSTD2 Monoclonal Antibody (SI539DS) FC IgG
MOR-4447 Hi-Affi™ Recombinant Rabbit Anti-TACSTD2 Monoclonal Antibody (SI540DS) WB, ELISA, IHC-P IgG
MOR-4448 Hi-Affi™ Recombinant Rabbit Anti-TACSTD2 Monoclonal Antibody (SI541DS) ICC/IF, FC, IF IgG
MOR-4449 Hi-Affi™ Recombinant Rabbit Anti-TACSTD2 Monoclonal Antibody (SI542DS) ELISA IgG

Recombinant Antibody

CAT Product Name Application Type
HPAB-0303CQ Mouse Anti-TACSTD2 Recombinant Antibody (clone AR47A6.4.2 (AR002)) ELISA, Inhib Mouse IgG2a, κ
HPAB-0304CQ Human Anti-TACSTD2 Recombinant Antibody (clone huAR47A6.4.2) FC, IP, WB, IHC, FuncS Human IgG1, κ
HPAB-0736-WJ Mouse Anti-TACSTD2 Recombinant Antibody (HPAB-0736-WJ) ELISA Mouse IgG
HPAB-0737-WJ Mouse Anti-TACSTD2 Recombinant Antibody (HPAB-0737-WJ) ELISA Mouse IgG
HPAB-0738-WJ Mouse Anti-TACSTD2 Recombinant Antibody (HPAB-0738-WJ) ELISA Mouse IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-627-FY-S(P) Human Anti-TACSTD2 Recombinant Antibody; scFv Fragment (HPAB-627-FY-S(P)) WB, FC, ELISA Human scFv
HPAB-628-FY-S(P) Human Anti-TACSTD2 Recombinant Antibody; scFv Fragment (HPAB-628-FY-S(P)) WB, FC, ELISA Human scFv
HPAB-0736-WJ-S(P) Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (HPAB-0736-WJ-S(P)) ELISA Mouse scFv
HPAB-0737-WJ-S(P) Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (HPAB-0737-WJ-S(P)) ELISA Mouse scFv
HPAB-0738-WJ-S(P) Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (HPAB-0738-WJ-S(P)) ELISA Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-627-FY-F(E) Human Anti-TACSTD2 Recombinant Antibody; Fab Fragment (HPAB-627-FY-F(E)) WB, FC, ELISA Humanized Fab
HPAB-628-FY-F(E) Human Anti-TACSTD2 Recombinant Antibody; Fab Fragment (HPAB-628-FY-F(E)) WB, FC, ELISA Humanized Fab
HPAB-0736-WJ-F(E) Mouse Anti-TACSTD2 Recombinant Antibody; Fab Fragment (HPAB-0736-WJ-F(E)) ELISA Mouse Fab
HPAB-0737-WJ-F(E) Mouse Anti-TACSTD2 Recombinant Antibody; Fab Fragment (HPAB-0737-WJ-F(E)) ELISA Mouse Fab
HPAB-0738-WJ-F(E) Mouse Anti-TACSTD2 Recombinant Antibody; Fab Fragment (HPAB-0738-WJ-F(E)) ELISA Mouse Fab

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