Anti-M1S1 (clone C16)-vc-MMAD ADC (CAT#: ADC-128LZY)

This ADC product is composed of an anti-M1S1 antibody (clone C16) conjugated via vc linker to MMAD (C16-vc-MMAD). It has demonstrated a response in pancreatic cancer treatment by a MOA (Mechanism of Action) as tubulin inhibitor.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Anti-M1S1 mAb,C16
  • Clone
  • C16
  • Linker
  • VC (valine-citrulline)
  • Linker Class/Description
  • Class: Enzymatically cleavable linker-Peptide linker
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAD (monomethyl auristatin D)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
  • Alternative Names
  • TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733;

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-1222z Mouse Anti-TACSTD2 Recombinant Antibody (clone 22B1) WB, IP, IF, IHC, ELISA Mouse IgG1, κ
HPAB-0597-YJ Mouse Anti-TACSTD2 Recombinant Antibody (clone KM4097) ELISA, FC, WB Mouse IgG1, κ
HPAB-0598-YJ Human Anti-TACSTD2 Recombinant Antibody (clone KM4591) ELISA, FC, ADCC, FuncS, WB Chimeric (mouse/human) IgG1, κ
HPAB-0599-YJ Human Anti-TACSTD2 Recombinant Antibody (clone huKM4097) ELISA, FC, ADCC, FuncS, WB Humanized IgG1, κ
HPAB-0600-YJ Mouse Anti-TACSTD2 Recombinant Antibody (clone AR47A6.4.2) ELISA, FC, WB, IP, FuncS Mouse IgG2a, κ

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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