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CBM4-2 anti-IgG4 (SCM-L054)

The CBM4-2 that bound Human IgG4 was isolated from the library using Phage display techonology. The CBM4-2, an 18-kDa protein derived from the xylanase (Xyn 10A) of Rhodothermus marinus, has a β-sandwich structure formed by 11 strands and contains no disulfide bonds. It is a well characterized module with defined substrate affinity and specificity. This module is thermostable and suitable for evolution of new binding properties. After affinity maturation, CBM4-2 variants were identified having affinities for Human IgG4 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Specifications
Scaffold Name
CBM4-2
Origin
Xylanase 10A (Xyn10A)
Core Structure
β-sandwich
Variable Regions
12 residues in carbohydrate binding site
Target
Human IgG4
Species Reactivity
Human
Expression Host
E. coli
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
xylanase 10A (Xyn10A); CBM4-2; IgG4

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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