CD4-Gel immunotoxin (AGTO-L021G)
This immunotoxin was achieved by conjugating/fusing the CD4 to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells infected with HIV. Once bind, the toxin enters cells by receptor-mediated endocytosis, then gelonin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of AIDS.
- Species Reactivity
- Molecule Class
- Toxin Description
- Gelonin is a glycoprotein (M.W. approximately 29-30, 000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Alternative Names
- HIV; human immunodeficiency virus; ADIS; Gelonin; Gel
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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