CTLA-4 (extracellular domain) scaffold protein anti-Human CD86 (CAT#: SCT-L249)
The CTLA-4 (extracellular domain) that bound CD86 was isolated from the library using Phage display techonology. After affinity maturation, CTLA-4 variants were identified having affinities for CD86 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HDLM-2
(Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26802/1962_A12_6_selected.jpg
(Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26802/1962_A12_6_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_B_8_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_B_8_5.jpg
Figure 3 Lung
(Macrophages Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_1_4.jpg
(Macrophages Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_1_4.jpg
Figure 4 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_8_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_8_3.jpg
Figure 5 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_9_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4319/11663_A_9_8.jpg
Figure 6 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000114013-CD86
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000114013-CD86
Specifications
- Scaffold Name
- CTLA-4 (extracellular domain)
- Origin
- CTLA-4
- Core Structure
- V-like Ig β-strands
- Variable Regions
- 1–2 loops
- Target
- CD86
- Species Reactivity
- Human
- Expression Host
- E. coli
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
- Alternative Names
- CTLA-4; CTLA-4 (extracellular domain); CD86; CD86 molecule; B70; B7-2; B7.2; LAB72; CD28LG2; T-lymphocyte activation antigen CD86; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); Hodgkin's lymphoma
- Gene ID
- 942
- UniProt ID
- A5D8T4
Related Resources
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Downloads
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Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L002G | anti-CD86 immunotoxin 1G10 (IgG)-Gel | Cytotoxicity assay, Functional assay | |
| AGTO-L002S | anti-CD86 immunotoxin 1G10 (IgG)-Sap | Cytotoxicity assay, Functional assay | |
| AGTO-L002O | anti-CD86 immunotoxin 1G10 (IgG)-Bouganin | Cytotoxicity assay, Functional assay |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-361LC | Anti-Human CD86 Recombinant Antibody (chFun1) | IHC | Chimeric antibody (mouse/human) |
| TAB-361LC-S(P) | Anti-Human CD86 Recombinant Antibody scFv Fragment (chFun1) | IHC | Chimeric antibody (mouse/human) |
| TAB-361LC-F(E) | Anti-Human CD86 Recombinant Antibody Fab Fragment (chFun1) | IHC | Chimeric antibody (mouse/human) |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-419CQ | Mouse Anti-CD86 Recombinant Antibody (clone MM0101-7F35) | WB, Neut, FC, CyTOF® | Mouse IgG1 |
| NEUT-420CQ | Mouse Anti-CD86 Recombinant Antibody (clone CBL763) | WB, FC, CyTOF®, Neut | Mouse IgG1 |
| NEUT-421CQ | Mouse Anti-CD86 Recombinant Antibody (clone CBL024) | Neut, FC | Mouse IgG1 |
| NEUT-422CQ | Mouse Anti-CD86 Recombinant Antibody (clone IT2.2) | FC, FuncS, Neut | Mouse IgG2b, κ |
| NEUT-426CQ | Rat Anti-Cd86 Recombinant Antibody (clone PO3.1) | FC, FuncS, Neut | Rat IgG2b, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-423CQ | Rat Anti-Cd86 Recombinant Antibody (clone 2D10), Biotin | FC, IHC-Fr, IP, Block | Rat IgG2b, κ |
| NEUT-424CQ | Rat Anti-Cd86 Recombinant Antibody (clone GL-1) | FC, Block, IF, IHC, IP | Rat IgG2a, κ |
| NEUT-425CQ | Rat Anti-Cd86 Recombinant Antibody (clone MAB0827) | Block, FC, IHC-Fr, IP | Rat IgG2 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0588 | Hi-Affi™ Rabbit Anti-CD86 Recombinant Antibody (clone DS588AB) | WB, FC, IHC | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-096CQ | Rat Anti-CD86 Recombinant Antibody (clone GL1) | IHC, FC, Block, IF | Rat IgG2a, κ |
| FAMAB-1678CQ | Mouse Anti-CD86 Recombinant Antibody (clone OX48) | FC, IF | Mouse IgG1 |
| FAMAB-1762CQ | Mouse Anti-CD86 Recombinant Antibody (clone PO.3) | Block, FuncS, WB, FC, IHC | Mouse IgG2a |
| VS3-CJ942 | Rabbit Anti-CD86 Recombinant Antibody (VS3-CJ942) | WB, ICC, IF, IHC, IP, FC | Rabbit IgG |
| VS3-XY426 | Mouse Anti-CD86 Recombinant Antibody, FITC (clone 4ABU63) | FC, IHC, IP, IF, WB | Mouse IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1586WJ-F(E) | Mouse Anti-CD86 Recombinant Antibody; Fab Fragment (clone 3D1) | ELISA, WB | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1586WJ-S(P) | Mouse Anti-CD86 Recombinant Antibody; scFv Fragment (clone 3D1) | ELISA, WB | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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