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Collagenase clostridium histolyticum (TP-066CL)

Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum that dismantles collagen. It is used as a powder-and-solvent injection kit for the treatment of Dupuytren's contracture, a condition where the fingers bend towards the palm and cannot be fully straightened, and Peyronie's disease, a connective tissue disorder involving the growth of fibrous plaques in the soft tissue of the penis. BioSpecifics Technologies developed the preparation, which is manufactured and marketed by Auxilium Pharmaceuticals as Xiaflex in the US and by Sobi as Xiapex in Europe.      

Specifications
Classify
Protein therapeutics providing a novel function or activity: Enzymatic degradation of macromolecules
Therapeutic
Collagenase
Trade Name
Collagenase, Santyl
Function
Collagenase obtained from fermentation by Clostridium histolyticum; digests collagen in necrotic base of wounds
Examples of Clinical Use
Debridement of chronic dermal ulcers and severely burned areas
References
Synonyms
Not Available

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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