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Denileukin diftitox (TP-105CL)

A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.      

Specifications
Classify
Protein therapeutics that deliver other compounds or proteins
Therapeutic
Denileukin diftitox
Trade Name
Ontak
Function
Directs the cytocidal action of diphtheria toxin to cells expressing the IL2 receptor
Examples of Clinical Use
Persistent or recurrent cutaneous T-cell lymphoma whose malignant cells express the CD25 component of the IL2 receptor
References
Synonyms
Diphtheria toxin precursor, DT, NAD(+--diphthamide ADP- ribosyltransferase)
UniProt
P00587
Genbank
V01536

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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