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Designed ankyrin repeat proteins (DARPins) anti-MAPK9 (SDA-L078)

The Designed ankyrin repeat protein (DARPins) that bound JNK2 was isolated from the library using Ribosome display techonology. DARPins (an acronym for designed ankyrin repeat proteins) are genetically engineered antibody mimetic proteins typically exhibiting highly specific and high-affinity target protein binding. After affinity maturation, DARPins variants were identified having affinities (KD=2.1 nM) for JNK2 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Specifications
Scaffold Name
Designed ankyrin repeat proteins (DARPins)
Origin
Designed ankyrin repeat proteins (DARPins)
Core Structure
α2/β2 repeated
Variable Regions
7 aa, on β-turn and first α-helix of every repeat
Target
JNK2
Species Reactivity
Human
Expression Host
E. coli
Affinity Constant
2.1 nM
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
ankyrin repeat (AR) proteins; Designed ankyrin repeat proteins (DARPins); JNK2; SAPK; p54a; JNK2A; JNK2B; PRKM9
Entrez Gene ID
5601
UniProt ID
P45984

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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