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Designed ankyrin repeat proteins (DARPins) anti-aphA1 (SDA-L076)

The Designed ankyrin repeat protein (DARPins) that bound APH was isolated from the library using Phage display techonology. DARPins (an acronym for designed ankyrin repeat proteins) are genetically engineered antibody mimetic proteins typically exhibiting highly specific and high-affinity target protein binding. After affinity maturation, DARPins variants were identified having affinities for APH as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Specifications
Scaffold Name
Designed ankyrin repeat proteins (DARPins)
Origin
Designed ankyrin repeat proteins (DARPins)
Core Structure
β-Hairpin-helix-loophelix (repeat)
Variable Regions
β-Turn, 1 α-helix and loop
Target
APH
Species Reactivity
E. coli
Expression Host
E. coli
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
Designed ankyrin repeat proteins (DARPins); Designed ankyrin repeat proteins (DARPins); Aminoglycoside-3'-phosphotransferase; aminoglycoside kinase; APH(3')
Entrez Gene ID
4246774

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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