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Dornase alfa (TP-067CL)

Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology. The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and 5´-phosphooligonucleotide end products without affecting intracellular DNA. In individuals with cystic fibrosis, extracellular DNA, which is an extremely viscous anion, is released by degenerating leukocytes that accumulate during inflammatory responses to infections. Enzymatic breakdown of this extracellular DNA appears to reduce sputum viscosity and viscoelasticity.      

Specifications
Classify
Protein therapeutics providing a novel function or activity: Enzymatic degradation of macromolecules
Therapeutic
Human deoxy- ribonuclease i, dornase-α
Trade Name
Pulmozyme
Function
Degrades DNA in purulent pulmonary secretions
Examples of Clinical Use
Cystic fibrosis; decreases respiratory tract infections in selected patients with Fvc greater than 40% of predicted
References
Synonyms
Deoxyribonuclease I, Deoxyribonuclease-1 precursor, DNase, DNase I, Dornase alfa (desoxyribonuclease), rhDNase
UniProt
P24855
Genbank
M55983

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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