Dornase alfa (CAT#: TP-067CL)

Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology. The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and 5´-phosphooligonucleotide end products without affecting intracellular DNA. In individuals with cystic fibrosis, extracellular DNA, which is an extremely viscous anion, is released by degenerating leukocytes that accumulate during inflammatory responses to infections. Enzymatic breakdown of this extracellular DNA appears to reduce sputum viscosity and viscoelasticity.


  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Classify
  • Protein therapeutics providing a novel function or activity: Enzymatic degradation of macromolecules
  • Therapeutic
  • Human deoxy- ribonuclease i, dornase-α
  • Trade Name
  • Pulmozyme
  • Function
  • Degrades DNA in purulent pulmonary secretions
  • Examples of clinical use
  • Cystic fibrosis; decreases respiratory tract infections in selected patients with Fvc greater than 40% of predicted

References

  • Synonyms
  • Deoxyribonuclease I, Deoxyribonuclease-1 precursor, DNase, DNase I, Dornase alfa (desoxyribonuclease), rhDNase
  • UniProt
  • P24855
  • Genbank
  • M55983

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-1636z Mouse Anti-DNASE1 Recombinant Antibody (clone 27C10) WB, IHC Mouse IgG

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