Products

Drotrecogin alfa (TP-052CL)

Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated that it was not effective in improving outcomes in patients with sepsis.      

Specifications
Classify
Protein therapeutics augmenting an existing pathway: Haemostasis and thrombosis
Therapeutic
Drotrecogin-α (activated protein C)
Trade Name
Xigris
Function
Antithrombotic (inhibits coagulation factors va and viiia), anti-inflammatory
Examples of Clinical Use
Severe sepsis with a high risk of death
References
Synonyms
Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Vitamin K-dependent protein C precursor
UniProt
P04070
Genbank
M11228

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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