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EETI-II anti-ELANE (SEE-L085)

The EETI-II that bound Neutrophil elastase was isolated from the library using mRNA display techonology. After affinity maturation, EETI-II variants were identified having affinities (KD=160 pM) for Neutrophil elastase as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Specifications
Scaffold Name
EETI-II
Origin
Trypsin-specific squash inhibitor EETI II
Core Structure
Coiled, cys-rich (28)
Variable Regions
6 aa
Target
Neutrophil elastase
Species Reactivity
Human
Expression Host
E. coli
Affinity Constant
160 pM
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
trypsin-specific squash inhibitor EETI II; EETI-II; GE; NE; HLE; HNE; ELA2; SCN1
Entrez Gene ID
1991
UniProt ID
P08246

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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