Products

EMCH (N-ε-maleimidocaproic acid hydrazide) (Glyco-018CL)

EMCH is a mid-length, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).      

Specifications
Product Size
50 mg
Spacer
Mid-Length
Solubility
Water
Labeling Method
Chemical Labeling
Crosslinker Type
Heterobifunctional
Specifications
We manufacture EMCH to the highest specifications to produce the most specific bioconjugates, ensure the integrity of your data and to provide you with the highest degree of consistency. Each lot of EMCH is tested to meet the following minimum specifications:

• NMR purity:>90%
• Melting point: 99-110°C
• Identity: IR scan shows only peaks characteristic of the structure and functional groups of EMCH
Contents & storage
Store desiccated at 4°C. Shipped at ambient temperature.
BACKGROUND
Description
3,3'-N-[ε-Maleimidocaproic acid] hydrazide, trifluoroacetic acid salt (EMCH) is a water-soluble, heterobifunctional, membrane permeable crosslinker. It contains a sulfhydryl reactive maleimide group and carbonyl reactive hydrazide group at each end of a 6-carbon spacer arm. Maleimides react with sulfhydryls at pH 6.5-7.5 to form stable thiol ether bonds, along with release of the maleimide leaving group. Proteins with cysteine residues not involved in disulfide bond formation are targets for maleimide reactive groups. Carbonyl groups, whilst not found naturally on proteins can be formed by ring sugar reduction to form aldehydes which react with hydrazides at pH5.5-7.5.
Properties

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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