Products

Etanercept (TP-087CL)

Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids      

Specifications
Classify
Protein therapeutics that interfere with a molecule or organism: Immunoregulation
Therapeutic
Etanercept
Trade Name
Enbrel
Function
Dimeric fusion protein between recombinant soluble TNF receptor and Fc portion of human immunoglobulin G1
Examples of Clinical Use
Rheumatoid arthritis, polyarticular-course juvenile rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis
References
Synonyms
CD120b, p75, p80 TNF-alpha receptor, TNF-R2, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor superfamily member 1B precursor, Tumor necrosis factor receptor type II
UniProt
P20333
Genbank
M32315

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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