Products

Galsulfase (TP-020CL)

Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate manose7 oligosaccharide for specific cellular recognition. Post-translational modification of Cys53 produces the catalytic amino acid residue Ca-formylglycine, which is required for enzyme activity and is conserved in all members of the sulfatase enzyme family.      

Specifications
Classify
Protein therapeutics replacing a protein that is deficient or abnormal: Metabolic enzyme deficiencies
Therapeutic
Galsulphase
Trade Name
Naglazyme
Function
Cleaves the terminal sulphate from the GAG dermatan sulphate, thereby allowing its digestion and preventing GAG accumulation
Examples of Clinical Use
Mucopolysaccharidosis vi
References
Synonyms
ARSB, Arylsufatase B

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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