Anti-Human MUC1 Recombinant Antibody (Gatipotuzumab) (CAT#: TAB-026ML)

Recombinant monoclonal antibody to MUC1. Gatipotuzumab is a human monoclonal antibody that can be potentially used in the treatment of Solid tumors.


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  • Tested Data
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Stim

Figure 1 Impact of Gatipotuzumab and 4-Hydroxy-Tamoxifen (4-OHT) on OC viability.

Figure 1 Impact of Gatipotuzumab and 4-Hydroxy-Tamoxifen (4-OHT) on OC viability.

Stimulation with Gatipotuzumab, 4-OHT and the combination of the two was performed in COV318, OV-90, SKOV-3, and OVCAR-3 cell lines over a 48-h and 72-h period. In general, Gatipotuzumab (Gati) alone only moderately reduced cell viability, while 4-OHT treatment appeared to be efficient in all the four cell lines tested (A-D). When viability of cells that had undergone co-stimulation was compared to that of those that had been treated with a single substance only, the overall net effect of co-stimulation was numerically slightly higher than the sum of individual effects of any of the two substances alone OVCAR-3 (C) and SKOV-3 (D). However, this was not statistically significant.

Heublein, S., Page, S., Mayr, D., Schmoeckel, E., Trillsch, F., Marmé, F.,... & Vattai, A. (2019). Potential Interplay of the Gatipotuzumab Epitope TA-MUC1 and Estrogen Receptors in Ovarian Cancer. International journal of molecular sciences, 20(2), 295.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • IgG1, κ
  • Specificity
  • Human MUC1
  • Species Reactivity
  • Human
  • Applications
  • ELISA, IHC, FC, IP, IF, FuncS, Stim
  • Conjugate
  • Unconjugated
  • CAS
  • 1264737-26-9
  • Generic Name
  • Gatipotuzumab
  • UNII
  • 85V55ZLV2Z
  • Related Disease
  • Solid tumors

Product Property

  • Purity
  • > 95% as determined by SDS-PAGE
  • Storage
  • Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Applications

  • Application Notes
  • The MUC1 antibody has been reported in applications of ELISA, IHC, FC, IP, IF, FuncS, Stim.

Target

  • Alternative Names
  • Mucin 1; polymorphic epithelial mucin; PEM; episialin; CD227

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Gatipotuzumab"

Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Gatipotuzumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to MUC1. Gatipotuzumab is a human monoclonal antibody that can be potentially used in the treatment of Solid tumors.

See other products for "MUC1"

Humanized Antibody

Immunotoxin

CAT Product Name Application Type
AGTO-L036E anti-MUC1 immunotoxin C242 (Fab)-PE Cytotoxicity assay, Functional assay
AGTO-L064E anti-MUC1 immunotoxin H23 (scFv)-PE Cytotoxicity assay, Functional assay

Fab Glycosylation

CAT Product Name Application Type
Gly-012LC Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) ELISA, FC, IHC Humanized antibody
Gly-120LC Recombinant Anti-Human MUC1 Antibody (Fab glycosylation) ELISA Mouse antibody

Sialylated IgG Glycan

CAT Product Name Application Type
Gly-012LC-1 Recombinant Anti-Human MUC1 Antibody (Fab glycosylation/Sialylated) ELISA, FC, IHC Humanized antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-109LC Recombinant Anti-Human MUC1 Antibody (Fc glycosylation) ELISA Human antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0379MZ Chicken Anti-MUC1 Polyclonal IgY IHC, WB Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2320 Hi-Affi™ Recombinant Rabbit Anti-MUC1 Monoclonal Antibody (DS2320AB) IHC-P, IHC-Fr IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H56 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Pemtumomab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-H65 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Sontuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF ADCC enhanced antibody
AFC-TAB-026ML Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Gatipotuzumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody
AFC-TAB-166 Afuco™ Anti-MUC1 ADCC Recombinant Antibody (Cantuzumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody
AFC-TAB-H77 Afuco™ Human Anti-MUC1 Recombinant Antibody, ADCC Enhanced (AFC-TAB-H77) ELISA, FC, IP, FuncS, IF IgG1, κ

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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