Anti-CD98 (clone IGNX)-mc-MMAF ADC (CAT#: ADC-108LZY)

This ADC product is composed of an anti-CD98 antibody (clone IGNX) conjugated via mc linker to MMAF (IGNX-mc-MMAF). It has demonstrated a response in lung carcinoma, ovarian tumor treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • IGNX(Anti-Human CD98 mAb)
  • Clone
  • IGNX
  • Linker
  • mc(maleimidocaproyl)
  • Linker Class/Description
  • Class: Noncleavable linker
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
  • Drug
  • MMAF(monomethyl auristatin F)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]
  • Alternative Names
  • SLC3A2; solute carrier family 3 (amino acid transporter heavy chain), member 2; 4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC; 4F2 cell-surface antigen heavy chain; CD98 heavy chain; monoclonal antibody 44D7; solute carrier family 3 member 2; lymphocyte activation antigen 4F2 large subunit; antigen defined by monoclonal antibody 4F2, heavy chain; antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43; solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2;

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Blocking Antibody

CAT Product Name Application Type
NEUT-1974CQ Recombinant Human Anti-SLC3A2 Antibody (HBJ127) BL, Activation, ELISA, IF IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3303 Hi-Affi™ Recombinant Rabbit Anti-SLC3A2 Monoclonal Antibody (DS3303AB) IHC-P, IP, WB IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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