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IL-15-DT immunotoxin (AGTO-G041D)

This immunotoxin was achieved by conjugating/fusing the IL-15 to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to interleukin-15 receptor (IL-15R)-overexpressing cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of arthritis.      

Specifications
Host
Rat
Species Reactivity
Human
Molecule Class
IL-15-DT
Toxin Description
Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
arthritis
Target
Alternative Names
IL15RA; interleukin 15 receptor, alpha; CD215; interleukin-15 receptor subunit alpha; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interleukin 15 receptor alpha isoform IC3; interleukin 15 receptor alpha isoform IC4
Entrez Gene ID
3601
UniProt ID
Q13261

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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