This immunotoxin was achieved by conjugating/fusing the IL-18 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to IL-18R–bearing antigen-presenting cells (APCs). Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating Experimental autoimmune encephalomyelitis (EAE).
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1369z | Mouse Anti-IL18R1 Recombinant Antibody (clone 22B12) | ELISA, WB, IP, FuncS | Mouse IgG1 |
MOB-0235CT | Recombinant Mouse anti-Human IL18R1 Monoclonal antibody (80736.222) | I-ELISA, Neut, WB | |
HPAB-658-FY | Mouse Anti-IL18R1 Recombinant Antibody (HPAB-658-FY) | FC | Mouse IgG |
HPAB-659-FY | Mouse Anti-IL18R1 Recombinant Antibody (HPAB-659-FY) | FC | Mouse IgG |
FAMAB-0315JF | Mouse Anti-IL18R1 Recombinant Antibody (clone 117-10C) | ELISA, FuncS | Mouse IgM, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G042D | IL-18-DT immunotoxin | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-207CT | Mouse Anti-IL18R1 Recombinant Antibody (TAB-207CT) | Neut, ELISA, Block | Mouse IgG |
TAB-208CT | Mouse Anti-IL18R1 Recombinant Antibody (TAB-208CT) | Neut, ELISA, Block | Mouse IgG |
TAB-209CT | Mouse Anti-IL18R1 Recombinant Antibody (TAB-209CT) | FC, ELISA, Ibhibition | Mouse IgG |
TAB-210CT | Mouse Anti-IL18R1 Recombinant Antibody (TAB-210CT) | FC, ELISA, Ibhibition | Mouse IgG |
TAB-207CT-S(P) | Mouse Anti-IL18R1 Recombinant Antibody; scFv Fragment (TAB-207CT-S(P)) | Neut, ELISA, Block | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-211CT | Human Anti-IL18R1 Recombinant Antibody (TAB-211CT) | FC, ELISA, Ibhibition | Humanized antibody |
TAB-211CT-S(P) | Human Anti-IL18R1 Recombinant Antibody; scFv Fragment (TAB-211CT-S(P)) | FC, ELISA, Ibhibition | Humanized scFv |
TAB-211CT-F(E) | Human Anti-IL18R1 Recombinant Antibody; Fab Fragment (TAB-211CT-F(E)) | FC, ELISA, Ibhibition | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1247CQ | Mouse Anti-IL18R1 Recombinant Antibody (clone CBL489) | FC, IHC, CyTOF, ICC, Neut | Mouse IgG1 |
NEUT-1248CQ | Mouse Anti-IL18R1 Recombinant Antibody (clone 70625.111) | I-ELISA, Neut, WB | Mouse IgG1 |
NEUT-1249CQ | Mouse Anti-IL18R1 Recombinant Antibody (clone 8H22) | IHC, Neut, WB | Mouse IgG1 |
NEUT-1250CQ | Rat Anti-Il18r1 Recombinant Antibody (clone CBL522) | WB, Neut | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4250 | Rabbit Anti-Il18r1 Recombinant Antibody (clone SI329DS) | ELISA | Rabbit IgG |
MOR-4251 | Rabbit Anti-IL18R1 Recombinant Antibody (clone SI330DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-658-FY-S(P) | Mouse Anti-IL18R1 Recombinant Antibody; scFv Fragment (HPAB-658-FY-S(P)) | Inhib, FC, ELISA | Mouse scFv |
HPAB-659-FY-S(P) | Mouse Anti-IL18R1 Recombinant Antibody; scFv Fragment (HPAB-659-FY-S(P)) | ELISA | Mouse scFv |
FAMAB-0315JF-S(P) | Mouse Anti-IL18R1 Recombinant Antibody (clone 117-10C); scFv Fragment | ELISA, FuncS | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-658-FY-F(E) | Mouse Anti-IL18R1 Recombinant Antibody; Fab Fragment (HPAB-658-FY-F(E)) | Inhib, FC, ELISA | Mouse Fab |
HPAB-659-FY-F(E) | Mouse Anti-IL18R1 Recombinant Antibody; Fab Fragment (HPAB-659-FY-F(E)) | ELISA | Mouse Fab |
FAMAB-0315JF-F(E) | Mouse Anti-IL18R1 Recombinant Antibody (clone 117-10C); Fab Fragment | ELISA, FuncS | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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