IL-18-PE immunotoxin (CAT#: AGTO-G042E)

This immunotoxin was achieved by conjugating/fusing the IL-18 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to IL-18R–bearing antigen-presenting cells (APCs). Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating Experimental autoimmune encephalomyelitis (EAE).


Specific Inquiry
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  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Mouse
  • Molecule Class
  • IL-18-PE
  • Toxin Description
  • Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Experimental autoimmune encephalomyelitis (EAE)

Target

  • Alternative Names
  • IL18R1; interleukin 18 receptor 1; Il1rrp; Il18ralpha; interleukin-18 receptor 1; IL-18R1; IL-1Rrp; IL1R-rp; IL-18R-1; IL1 receptor-related protein; CD218 antigen-like family member A; interleukin 1 receptor related protein; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE68

Related Resources

  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Immunotoxin

CAT Product Name Application Type
AGTO-G042D IL-18-DT immunotoxin Cytotoxicity assay, Function study

Humanized Antibody

CAT Product Name Application Type
TAB-211CT Human Anti-IL18R1 Recombinant Antibody (TAB-211CT) FC, ELISA, Ibhibition Humanized antibody
TAB-211CT-S(P) Human Anti-IL18R1 Recombinant Antibody; scFv Fragment (TAB-211CT-S(P)) FC, ELISA, Ibhibition Humanized scFv
TAB-211CT-F(E) Human Anti-IL18R1 Recombinant Antibody; Fab Fragment (TAB-211CT-F(E)) FC, ELISA, Ibhibition Humanized Fab

Neutralizing Antibody

Rabbit Monoclonal Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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