This immunotoxin was achieved by conjugating/fusing the IL6 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to IL6 expressing cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of myeloma.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-026 | Anti-Human IL6R Recombinant Antibody (Tocilizumab/Atlizumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
TAB-691LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-691LC-S(P)) | ELISA | Humanized scFv |
TAB-692LC-S(P) | Anti-human IL6R scFv Fragment (BOW070) | ELISA | Humanized antibody |
TAB-696LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-696LC-S(P)) | ELISA | Humanized scFv |
TAB-697LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-697LC-S(P)) | ELISA | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L080D | IL6-DT immunotoxin | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-245 | Human Anti-IL6R Recombinant Antibody (clone 6RL9); scFv Fragment | WB, Neut, FuncS | Human scFv |
HPAB-0016-YC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0016-YC-S(P)) | ELISA, Neut | Human scFv |
HPAB-0446-WJ-S(P) | Mouse Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0446-WJ-S(P)) | ELISA | Mouse scFv |
HPAB-0447-WJ-S(P) | Mouse Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0447-WJ-S(P)) | ELISA | Mouse scFv |
HPAB-0448-WJ-S(P) | Mouse Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0448-WJ-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-690LC | Anti-human IL6R Recombinant Antibody (PM-1) (TAB-690LC) | ELISA | |
TAB-694LC | Rabbit Anti-IL6R Recombinant Antibody (TAB-694LC) | ELISA | Rabbit IgG |
TAB-690LC-S(P) | Anti-human IL6R scFv Fragment (PM-1) | ELISA | |
TAB-694LC-S(P) | Rabbit Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-694LC-S(P)) | ELISA | Rabbit scFv |
TAB-695LC-S(P) | Rabbit Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-695LC-S(P)) | ELISA | Rabbit scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1485CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL212) | FC, ELISA, Neut | Mouse IgG1, κ |
NEUT-1486CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL261) | FC, Neut | Mouse IgG1 |
NEUT-1487CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL279) | Neut, WB, ELISA, FC | Mouse IgG1 |
NEUT-1489CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL425) | WB, FC, CyTOF, ELISA, Neut | Mouse IgG1 |
NEUT-1491CQ | Mouse Anti-IL6R Recombinant Antibody (clone MM0409-6M30) | WB, Neut | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1488CQ | Mouse Anti-IL6R Recombinant Antibody (clone B-F19) | Block | Mouse IgG1 |
NEUT-1490CQ | Mouse Anti-IL6R Recombinant Antibody (clone B-R6) | IHC-Fr, Inhib, FC, IP | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0718-CN | Human Anti-IL6R Recombinant Antibody (HPAB-0718-CN) | ELISA, Neut | Humanized IgG1 |
HPAB-0719-CN | Human Anti-IL6R Recombinant Antibody (HPAB-0719-CN) | ELISA, Neut | Humanized IgG1 |
HPAB-0720-CN | Human Anti-IL6R Recombinant Antibody (HPAB-0720-CN) | ELISA, Neut | Humanized IgG1 |
HPAB-0251CQ | Human Anti-IL6R Recombinant Antibody (HPAB-0251CQ) | ELISA, FC, Block | Human IgG4 |
HPAB-0034-WJ | Mouse Anti-IL6R Recombinant Antibody (clone 8C1D8B5) | ELISA, WB | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0034-WJ-F(E) | Mouse Anti-IL6R Recombinant Antibody (clone 8C1D8B5); Fab Fragment | ELISA, WB | Mouse Fab |
HPAB-1761LY-F(E) | Mouse Anti-IL6R Recombinant Antibody (clone G10); Fab Fragment | FC | Mouse Fab |
HPAB-0165-YJ-F(E) | Human Anti-IL6R Recombinant Antibody; Fab Fragment (HPAB-0165-YJ-F(E)) | ELISA, Block, Inhib | Humanized Fab |
HPAB-0446-WJ-F(E) | Mouse Anti-IL6R Recombinant Antibody; Fab Fragment (HPAB-0446-WJ-F(E)) | ELISA | Mouse Fab |
HPAB-0447-WJ-F(E) | Mouse Anti-IL6R Recombinant Antibody; Fab Fragment (HPAB-0447-WJ-F(E)) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-026 | Afuco™ Anti-IL6R ADCC Recombinant Antibody (Tocilizumab/Atlizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-032ML | Afuco™ Anti-IL6R ADCC Recombinant Antibody (Satralizumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-691LC | Afuco™ Anti-IL6R ADCC Recombinant Antibody (Sapelizumab), ADCC Enhanced | ELISA | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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